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KMID : 0880220120500061067
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Journal of Microbiology
2012 Volume.50 No. 6 p.1067 ~ p.1070
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Susceptibility of human H3N2 influenza virus to oseltamivir in South Korea, 2009?2011
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Park Se-Hee
Kim Jin-Il
Lee Il-Seob
Lee Sang-Moo
Hwang Min-Woong
Bae Joon-Yong
Heo Jun
Park Man-Seong
Lim Eun-Joo
Seok Won-Seok
Cheong Hee-Jin
Song Joon-Young
Kim Woo-Joo
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Abstract
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During the 2009?2011 influenza seasons, 10.26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.
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KEYWORD
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influenza, neuraminidase, oseltamivir
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